Synthesis and Cytotoxicity of Emodin Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (08): 944-948. Previous Articles Next Articles

Original Articles

大黄素衍生物的合成及细胞毒性研究

陆豫，黄志纾*，谭嘉恒，丁岩，卜宪章
安林坤，马林，符立梧，古练权

(¹中山大学药学院广州 510080)
(²中山大学化学与化工学院广州 510275)
(³江西中德联合研究院南昌 330047)
(⁴中山大学肿瘤防治中心广州 510060)

收稿日期:2004-08-05 修回日期:2005-02-28 发布日期:2005-07-30
通讯作者: 黄志纾

Synthesis and Cytotoxicity of Emodin Derivatives

LU Yu,HUANG Zhi-Shu*,TAN Jia-Heng,DING Yan,BU Xian-Zhang
AN Lin-Kun,MA Lin,FU Li-Wu,GU Lian-Quan

(¹School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510080)
(²School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275)
(³Jiangxi China-Germany Joint Research Institute, Nanchang 330047)
(⁴Cancer Center, Sun Yat-Sen University, Guangzhou 510060)

Received:2004-08-05 Revised:2005-02-28 Published:2005-07-30
Contact: HUANG Zhi-Shu

Abstract

A series of new emodin derivatives 6～14 containing nitrogen atoms have been synthesized. Their structures were established by ¹H NMR, IR, MS spectra and elemental analyses. The cytotoxicity bioassays of these new emodin derivatives were carried out using the standard MTT method, and most of emodin derivatives showed potent cytotoxicity. The mixture of positional isomers 7a and 7b demonstrated the strongest cytotoxicity activity against the cell line of KB and MCF-7.

Key words: synthesis, emodin derivative, cytotoxicity

Cite this article

LU Yu,HUANG Zhi-Shu*,TAN Jia-Heng,DING Yan,BU Xian-Zhang
AN Lin-Kun,MA Lin,FU Li-Wu,GU Lian-Quan. Synthesis and Cytotoxicity of Emodin Derivatives[J]. Chin. J. Org. Chem., 2005, 25(08): 944-948.

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大黄素衍生物的合成及细胞毒性研究

Synthesis and Cytotoxicity of Emodin Derivatives

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