Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]pro-pyl}-1,2,3,4-tetrahydronaphthalen-1-ones under Solvent-Free Condi-tion

Abstract

The synthesis of 2-{3-oxo-1,3-di[(un)substituted phenyl]propyl}-1,2,3,4-tetrahydronaphthalen- 1-ones from chalcones and 1-tetralone was carried out in excellent yields in the presence of K₂CO₃-NaOH under a solvent-free condition at room temperature using a grinding method. This protocol has the advantages of mild reaction conditions, simple procedure and high yields. The structures of the products were characterized on the basis of IR, ¹H NMR spectroscopic data, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, 1-tetralone, solvent-free, synthesis

Cite this article

RONG Liang-Ce*^,a,b,HAN Hong-Xia^a,JIANG Hong^b,LI Xiao-Yue^a
YAO Chang-Sheng^a,TU Shu-Jiang,b. Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]pro-pyl}-1,2,3,4-tetrahydronaphthalen-1-ones under Solvent-Free Condi-tion[J]. Chin. J. Org. Chem., 2008, 28(04): 746-749.

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无溶剂条件下合成2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮