A series of 2-[5-(substituted phenyloxy)methyl-1,3,4-thiadiazol-2-ylimino]-5-(substituted ben-zylidene)-4-thiazolidinones (4a～4p) were synthesized by quasi-Knoevenagel condensation of 2-[5-(substi- tuted phenyloxy)methyl-1,3,4-thiadiazol-2-ylimino]-4-thiazolidinones (3) with substituted benzaldehydes. The intermediates 3 and 2-chloroacetamido-5-(substituted phenyloxy)methyl-1,3,4-thiadiazoles (2) were prepared by using 2-amino-5-(substituted phenyloxy)methyl-1,3,4-thiadiazoles (1) as a starting material. The structures of 4a～4p were confirmed by IR, ¹H NMR spectra and elemental analyses.

Key words: thiazolidinone derivative, synthesis, 2-[5-(substituted phenyloxy)methyl-1,3,4-thiadiazol-2-ylimino]-5-(substituted benzylidene)- 4-thiazo