Synthesis of 3-Indolyl-substituted Phthalides Catalyzed by Acidic Cation Exchange Resin Amberlyst 15

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1479-1482. Previous Articles Next Articles

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固体酸Amberlyst 15催化合成3-吲哚取代的苯酞类化合物

林华^a ; 韩京成^a ; 孙兴文^*,a; 林国强^*,a,b

(a复旦大学化学系上海 200433)
(b中国科学院上海有机化学研究所上海 200032)

收稿日期:2008-06-02 修回日期:2008-06-06 发布日期:2008-08-18
通讯作者: 孙兴文*,a; 林国强*,a,b

Synthesis of 3-Indolyl-substituted Phthalides Catalyzed by Acidic Cation Exchange Resin Amberlyst 15

LIN, Hua^a ; HAN, Kyong-Sung^a; SUN, Xing-Wen^*,a ; LIN, Guo-Qiang^*,a,b

(a Department of Chemistry, Fudan University, Shanghai 200433)
(b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

Received:2008-06-02 Revised:2008-06-06 Published:2008-08-18
Contact: SUN, Xing-Wen*,a;LIN, Guo-Qiang*,a,b

Abstract

A mild and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids catalyzed by an acidic cation exchange resin Amberlyst 15 has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in high yield. The structures of the corresponding products were confirmed on the basis of 1H NMR, 13C NMR, IR and HRMS spectra.

Key words: Amberlyst 15, phthalide, synthesis, Friedel-Crafts reaction, 3-indolyl-subtituted phthalide, indole

Cite this article

LIN, Hua^a ; HAN, Kyong-Sung^a; SUN, Xing-Wen^*,a ; LIN, Guo-Qiang^*,a,b. Synthesis of 3-Indolyl-substituted Phthalides Catalyzed by Acidic Cation Exchange Resin Amberlyst 15[J]. Chin. J. Org. Chem., 2008, 28(08): 1479-1482.

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固体酸Amberlyst 15催化合成3-吲哚取代的苯酞类化合物

Synthesis of 3-Indolyl-substituted Phthalides Catalyzed by Acidic Cation Exchange Resin Amberlyst 15

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