Design and Synthesis of Novel Ester-type Molecular Tweezers Derived from Chenodeoxycholic Acid

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 679-683. Previous Articles Next Articles

Original Articles

新型酯键型鹅去氧胆酸分子钳的设计合成

赵志刚，张佩玉，杨祖幸，陈淑华*

(四川大学化学学院成都 610064)

收稿日期:2004-08-05 修回日期:2004-12-21 发布日期:2005-05-30
通讯作者: 陈淑华

Design and Synthesis of Novel Ester-type Molecular Tweezers Derived from Chenodeoxycholic Acid

ZHAO Zhi-Gang, ZHANG Pei-Yu, YANG Zu-Xing, CHEN Shu-Hua*

(Faculty of Chemistry, Sichuan University, Chengdu 610064)

Received:2004-08-05 Revised:2004-12-21 Published:2005-05-30
Contact: CHEN Shu-Hua

Abstract

A novel type of chiral molecular tweezers has been designed and synthesized by using chenodeoxycholic acid as spacer and aromatic compounds as arm. Their structures were confirmed by ¹H NMR, IR, MS spectra and elemental analysis. Their recognition properties for methyl esters of amino acids were investigated. The preliminary results indicate that these chiral molecular tweezers are favorable for complexation with D-amino acid methyl esters.

Key words: chenodeoxycholic acid, synthesis, molecular tweezer

Cite this article

ZHAO Zhi-Gang, ZHANG Pei-Yu, YANG Zu-Xing, CHEN Shu-Hua*. Design and Synthesis of Novel Ester-type Molecular Tweezers Derived from Chenodeoxycholic Acid[J]. Chin. J. Org. Chem., 2005, 25(06): 679-683.

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新型酯键型鹅去氧胆酸分子钳的设计合成

Design and Synthesis of Novel Ester-type Molecular Tweezers Derived from Chenodeoxycholic Acid

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