Synthesis and Structural Characterization of 2,4-Bis[(3-aryl)-1,2,4- triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] Derivatives of Pyridine under Microwave Irradiation

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (05): 764-767. Previous Articles Next Articles

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2,4-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]吡啶类衍生物的微波合成与结构表征

王晓庆，赵志刚*，李伟杰，刘兴利，韩涛

(西南民族大学化学与环境保护工程学院成都 610041)

收稿日期:2009-12-30 修回日期:2010-03-10 发布日期:2010-03-24
通讯作者: 赵志刚 E-mail:zzg63129@yahoo.com.cn

Synthesis and Structural Characterization of 2,4-Bis[(3-aryl)-1,2,4- triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] Derivatives of Pyridine under Microwave Irradiation

WANG Xiao-Qing, ZHAO Zhi-Gang, LI Wei-Jie, LIU Xing-Li, HAN Tao

(College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)

Received:2009-12-30 Revised:2010-03-10 Published:2010-03-24
Contact: Zhi-Gang ZHAO E-mail:zzg63129@yahoo.com.cn

Abstract

Ten novel 2,4-bis[(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] derivatives of pyridine have been synthesized via reaction of 1,2,4-triazole with 2,4-pyridinedicarboxylic acid catalyzed by POCl₃ under microwave irradiation, with the view of providing lead compounds for the screening of new dugs. The structures of all new compounds were characterized by ¹H NMR, IR, MS techniques and elemental analysis.

Key words: triazole, bis[triazolo[3,4-b]-thiadiazole], microwave, synthesis

Cite this article

WANG Xiao-Qing, ZHAO Zhi-Gang, LI Wei-Jie, LIU Xing-Li, HAN Tao. Synthesis and Structural Characterization of 2,4-Bis[(3-aryl)-1,2,4- triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] Derivatives of Pyridine under Microwave Irradiation[J]. Chin. J. Org. Chem., 2010, 30(05): 764-767.

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2,4-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]吡啶类衍生物的微波合成与结构表征

Synthesis and Structural Characterization of 2,4-Bis[(3-aryl)-1,2,4- triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] Derivatives of Pyridine under Microwave Irradiation

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