Synthesis of Methyl 4-Substituted-phenyl-2,3-dihydro-1,5- benzothi-azepine-3-acetates and Their Sodium Salts

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (12): 1939-1943. Previous Articles Next Articles

Notes

4-取代苯基-2,3-二氢-1,5-苯并硫氮杂-3-乙酸甲酯及其钠盐的合成

张萍¹，黄金华¹，王兰芝¹，刘薇²，李媛*^,1

(¹河北师范大学化学与材料科学学院石家庄 050016)
(²河北师范大学生命科学学院石家庄 050016)

收稿日期:2010-01-05 修回日期:2010-05-25 发布日期:2010-07-15
通讯作者: 张萍 E-mail:zhangpingp@sina.com
基金资助:
国家自然科学基金;河北省自然科学基金;河北省教育厅自然科学基金项目

Synthesis of Methyl 4-Substituted-phenyl-2,3-dihydro-1,5- benzothi-azepine-3-acetates and Their Sodium Salts

Zhang Ping¹ Huang Jinhua¹ Wang Lan-zhi¹ Liu Wei² Li Yuan*^,1

(¹ College of Chemistry, Hebei Normal University, Shijiazhuang 050016)
(² College of Life Science, Hebei Normal University, Shijiazhuang 050016)

Received:2010-01-05 Revised:2010-05-25 Published:2010-07-15

Abstract

Starting from substituted benzenes, methyl 3-methylene-4-substituted phenyl-4-oxo-butanate (1a～1g) were synthesized by Friedel-Crafts acetylation, esterification and Mannich reaction, then reacted with 2-amino benzenethiol getting a series of methyl 4-substituted-phenyl-2,3-dihydro-1,5-benzothiazepine- 3-acetates and their sodium salts. The structures of the new products were confirmed by ¹H NMR, IR, MS techniques and elemental analysis.

Key words: 1,5-benzothiazepines, Mannich reaction, synthesis

Cite this article

ZHANG Ping, HUANG Jin-Hua, WANG Lan-Zhi, LIU Wei, LI Yuan. Synthesis of Methyl 4-Substituted-phenyl-2,3-dihydro-1,5- benzothi-azepine-3-acetates and Their Sodium Salts[J]. Chin. J. Org. Chem., 2010, 30(12): 1939-1943.

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4-取代苯基-2,3-二氢-1,5-苯并硫氮杂-3-乙酸甲酯及其钠盐的合成

Synthesis of Methyl 4-Substituted-phenyl-2,3-dihydro-1,5- benzothi-azepine-3-acetates and Their Sodium Salts

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