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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (01): 87-95. Previous Articles     Next Articles

Full Papers

L-乳酸齐聚物的制备及其三羰基铼衍生物的合成

朱华1,2，黄立梁1,2，张元庆1,2，沈玉梅*,1   

  1. (1中国科学院上海应用物理研究所 放射性药物研究中心 上海 201800)
    (2中国科学院研究生院 北京 100049)
  • 收稿日期:2010-03-02 修回日期:2010-06-30 发布日期:2010-08-19
  • 通讯作者: 沈玉梅 E-mail:shenyumei@sinap.ac.cn;ymshencsu@yahoo.com
  • 基金资助:

    中国科学院“百人计划”;国家自然科学基金

Synthesis of Molecularly Defined (L)-Lactic Acid Oligomers and Its Tricarbonyl Rhenium Derivatives

Zhu Hua1,2 Huang Liliang1,2 Zhang Yuan-qing1,2 Shen Yumei*,1   

  1. (1 Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800)
    (2 Graduate School of the Chinese Academy of Sciences, Beijing 100049)
  • Received:2010-03-02 Revised:2010-06-30 Published:2010-08-19
  • Supported by:

    Hundred Talent Program of Chinese Academy of Sciences

PDF

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Modification of the (L)-lactide hydroxyl and carboxylic acid groups was conducted by careful selection of orthogonal protective groups. Three series of lactide oligomers were synthesized for potential industrial production. Starting from Latide-Hexamer, synthesis of hydroxyl tailored biodegradable LA-PEG oligomers, and chelating to tricarbonyl rhenium(I) for medicinal applications were described. The structures of final products and the intermediates were confirmed by IR, 1H NMR, 13C NMR, HRMS, MALDI-HRMS or elemental analysis. The preparation of these lactide oligomers would have a wide range of applications in organic synthesis, molecular imaging and so on.

Key words: lactic acid, ethylene glycol, oligomer, tricarbony rheniuml, synthesis