A Novel, Green and Mild Access to Azole Heteroarenes: Synthesis of Pyrazoles in Brønsted Acidic Ionic Liquid at Room Tem-perature

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (03): 387-391. Previous Articles Next Articles

Notes

一种新的绿色、温和的合成唑杂环的方法：在室温酸性离子液体中合成吡唑类化合物

张岩，金宏，尤心稳，商志才*

(浙江大学化学系杭州 310027)

收稿日期:2010-05-30 修回日期:2010-09-12 发布日期:2010-10-26
通讯作者: Zhicai Shang E-mail:shangzc@zju.edu.cn

A Novel, Green and Mild Access to Azole Heteroarenes: Synthesis of Pyrazoles in Brønsted Acidic Ionic Liquid at Room Tem-perature

ZHANG Yan, JIN Hong, YOU Xin-Wen, SHANG Zhi-Cai

(Department of Chemistry, Zhejiang University, Hangzhou 310027)

Received:2010-05-30 Revised:2010-09-12 Published:2010-10-26
Contact: SHANG Zhi-Cai E-mail:shangzc@zju.edu.cn

Abstract

A novel pyrazole synthesis approach has been developed by using Brønsted acidic ionic liquid BMImHSO₄, which acts as dual solvent-catalyst in promoting the condensation of hydrazines with various 1,3-dicarbonyl compounds at room temperature. In the reaction process, no catalysts or other organic solvents are used, and BMImHSO₄ can be readily reused without efficiency loss after simple treatment. This provides a green and mild synthetic method for the preparation of this class of heterocyclic compounds.

Key words: pyrazole, ionic liquid, BMImHSO₄, synthesis, reuse

Cite this article

ZHANG Yan, JIN Hong, YOU Xin-Wen, SHANG Zhi-Cai. A Novel, Green and Mild Access to Azole Heteroarenes: Synthesis of Pyrazoles in Brønsted Acidic Ionic Liquid at Room Tem-perature[J]. Chin. J. Org. Chem., 2011, 31(03): 387-391.

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一种新的绿色、温和的合成唑杂环的方法：在室温酸性离子液体中合成吡唑类化合物

A Novel, Green and Mild Access to Azole Heteroarenes: Synthesis of Pyrazoles in Brønsted Acidic Ionic Liquid at Room Tem-perature

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