Synthesis of Spirooxindole Derivatives under Solvent- and Catalyst-Free Conditions

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (04): 553-556. Previous Articles Next Articles

Notes

无催化剂、无溶剂条件下合成螺氧化吲哚衍生物

赵丽琴，周波，李毅群*

(暨南大学化学系广州 510632)

收稿日期:2010-08-27 修回日期:2010-11-07 发布日期:2010-11-26
通讯作者: 李毅群 E-mail:tlyq@jnu.edu.cn

Synthesis of Spirooxindole Derivatives under Solvent- and Catalyst-Free Conditions

ZHAO Li-Qin, ZHOU Bo, LI Yi-Qun

(Department of Chemistry, Jinan University, Guangzhou 510632)

Received:2010-08-27 Revised:2010-11-07 Published:2010-11-26
Contact: Li Yi-Qun E-mail:tlyq@jnu.edu.cn

Abstract

An efficient, clean and environmentally benign protocol for synthesis of spirooxindole derivatives via one pot three-component reaction from isatins, malononitrile and 1,3-dicarbonyl compounds was archived at 80 ℃ under solvent- and catalyst-free conditions. The advantageous of this procedure were mild reaction conditions, convenient operation, excellent yields and benign to environment.

Key words: catalyst-free, solvent-free, grinding, spirooxindole derivative

Cite this article

ZHAO Li-Qin, ZHOU Bo, LI Yi-Qun. Synthesis of Spirooxindole Derivatives under Solvent- and Catalyst-Free Conditions[J]. Chin. J. Org. Chem., 2011, 31(04): 553-556.

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无催化剂、无溶剂条件下合成螺氧化吲哚衍生物

Synthesis of Spirooxindole Derivatives under Solvent- and Catalyst-Free Conditions

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