Design, Synthesis and Biological Activity of E-β-Farnesene Analogues Containing Pyra-zole-carboxamide

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1425-1432. Previous Articles Next Articles

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含吡唑甲酰胺基E-β-法尼烯类似物的设计、合成及生物活性

孙玉凤，李永强，凌云，宇红莲，杨绍祥，杨新玲*

(中国农业大学理学院应用化学系农业部农药化学与应用重点开放实验室北京 100193)

收稿日期:2011-01-10 修回日期:2011-02-26 发布日期:2011-04-14

Design, Synthesis and Biological Activity of E-β-Farnesene Analogues Containing Pyra-zole-carboxamide

SUN Yu-Feng, LI Yong-Qiang, LING Yun, YU Hong-Lian, YANG Shao-Xiang, YANG Xin-Ling

(Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193)

Received:2011-01-10 Revised:2011-02-26 Published:2011-04-14

Abstract

In order to discover novel compounds used to control aphids, twenty E-β-farnesene (EBF) analogues containing pyrazole-carboxamide were designed and synthesized with the aphid alarm pheromone EBF as the lead. Their structures were confirmed by ¹H NMR, IR and HRMS techniques. The preliminary bioassay showed that some title compounds exhibit insecticidal activity against fifth-instar Aphis craccivora Koch nymphs at 600 mg/L, especially 5a and 5k showed comparable aphicidal activity with commercial fipronil and lead (EBF), or even better than EBF. The factors influencing the activity of the compounds were discussed.

Key words: pyrazole, EBF analogues, synthesis, biological activity

Cite this article

SUN Yu-Feng, LI Yong-Qiang, LING Yun, YU Hong-Lian, YANG Shao-Xiang, YANG Xin-Ling. Design, Synthesis and Biological Activity of E-β-Farnesene Analogues Containing Pyra-zole-carboxamide[J]. Chin. J. Org. Chem., 2011, 31(9): 1425-1432.

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含吡唑甲酰胺基E-β-法尼烯类似物的设计、合成及生物活性

Design, Synthesis and Biological Activity of E-β-Farnesene Analogues Containing Pyra-zole-carboxamide

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