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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (10): 1639-1642. Previous Articles     Next Articles

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新型呋喃基Schiff碱衍生物的合成、结构和生物活性

严琳1，刘丰五2，刘宏民*,2   

  1. (1河南大学化学生物学研究所 开封 475004)
    (2郑州大学新药研究开发中心 郑州 450001)
  • 收稿日期:2011-02-21 修回日期:2011-05-13 发布日期:2011-05-27
  • 通讯作者: 严琳 E-mail:yanlin@henu.edu.cn

Synthesis, Structure and Biological Activities of Novel Furanosyl Schiff Base Derivatives

Yan Lin1 Liu Fengwu2 Liu Hongmin*,2   

  1. (1 Institute of Chemistry & Biology, Henan University, Kaifeng 475004)
    (2 New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001)
  • Received:2011-02-21 Revised:2011-05-13 Published:2011-05-27
  • Contact: Lin YAN E-mail:yanlin@henu.edu.cn

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Schiff base compounds have significant antitumor, antimicrobial and antiviral activities. In this study, some new α,β-unsaturated aldehydes were synthesized through oxidation and dehydration reaction. Then a series of furanosyl Schiff base derivatives were synthesized by condensation reaction of α,β-unsaturated aldehydes with various phenylamines. The preliminary biological activities of these furanosyl Schiff base derivatives were also investigated.

Key words: furanosyl Schiff base derivative, synthesis, crystal structure, biological activity