Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1715-1718.DOI: 10.6023/cjoc1202242 Previous Articles     Next Articles

Articles

N-芳亚甲基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑-2-胺的合成与生物活性

戴红a,b, 周欣a, 邵玲a, 刘建兵a, 秦雪a, 方建新a   

  1. a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019
  • 收稿日期:2012-02-24 修回日期:2012-05-11 发布日期:2012-03-30
  • 通讯作者: 方建新 E-mail:daihong_2001@yahoo.com.cn, fjx@nankai.edu.cn
  • 基金资助:

    国家自然科学基金(No.20772068)、南通市科技计划(Nos.AS2010005, AS2011011)资助项目

Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine

Dai Honga,b, Zhou Xina, Shao Linga, Liu Jianbinga, Qin Xuea, Fang Jianxina   

  1. a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2012-02-24 Revised:2012-05-11 Published:2012-03-30
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Projects Fund of Nantong City (Nos.AS2010005, AS2011011)

Reaction of 2-amino-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazole with various substituted benzal-dehydes produced a series of novel thiazole Schiff bases containing 1H-1,2,4-triazole ring. Their structures were characterized by 1H NMR spectra and elemental analysis. The bioassay data indicated that some of the title compounds showed certain antitumor activities.

Key words: thiazole, 1H-1,2,4-triazole, synthesis, bioactivity