Synthesis of 9-Acetoxyethyl-6-alkylamino-2-alkylthio Purines and Their Anti-platelet Aggregation Activity

doi:10.6023/cjoc1203091

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1678-1683.DOI: 10.6023/cjoc1203091 Previous Articles Next Articles

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9-乙酰氧基乙基-6-烷氨基-2-烷硫基嘌呤的合成及抗血小板凝集活性评估

何琦文, 杜洪光

北京化工大学理学院北京 100029

收稿日期:2012-03-09 修回日期:2012-05-22 发布日期:2012-04-22
通讯作者: 杜洪光 E-mail:dhg@mail.buct.edu.cn

Synthesis of 9-Acetoxyethyl-6-alkylamino-2-alkylthio Purines and Their Anti-platelet Aggregation Activity

He Qiwen, Du Hongguang

College of Science, Beijing University of Chemical Technology, Beijing 100029

Received:2012-03-09 Revised:2012-05-22 Published:2012-04-22

2-Amino-6-chloropurine (1) as the starting material was treated with 2-bromoethyl acetate to yield 9-acetoxy-ethyl-2-amino-6-chloropurine (2). Compound 2 was diazotized and reacted with disulfides to afford 9-acetoxyethyl-2-alkythio-6-chloropurine (3). 9-Acetoxyethyl-6-alkylamino-2-alkylthio purines (4) were acquired by aminolysis reaction of compounds 3. Their structures were determined by IR,¹H NMR,¹³C NMR and HRMS techniques. Meanwhile, the anti-platelet aggregation rates of compounds 4 were measured.

Key words: 6-alkylamino-2-alkylthio purine, synthesis, characterization, anti-platelet aggregation

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He Qiwen, Du Hongguang. Synthesis of 9-Acetoxyethyl-6-alkylamino-2-alkylthio Purines and Their Anti-platelet Aggregation Activity[J]. Chin. J. Org. Chem., 2012, 32(9): 1678-1683.

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9-乙酰氧基乙基-6-烷氨基-2-烷硫基嘌呤的合成及抗血小板凝集活性评估

Synthesis of 9-Acetoxyethyl-6-alkylamino-2-alkylthio Purines and Their Anti-platelet Aggregation Activity

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