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Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (07): 1503-1508.DOI: 10.6023/cjoc201210044 Previous Articles     Next Articles

Articles

2-烷氧羰基烷基/正丁基-4-芳基-1,5-苯并硫氮杂(卄卓)类化合物的合成及抑菌活性的研究

李文红a,b, 刘喜莹a, 张博a, 李媛a   

  1. a 河北师范大学化学与材料科学学院 石家庄 050024;
    b 河北工业职业技术学院环境与化学工程系 石家庄 050091
  • 收稿日期:2013-10-23 修回日期:2013-01-18 发布日期:2013-02-22
  • 通讯作者: 李媛 E-mail:liyuanhbsd@163.com
  • 基金资助:

    国家自然科学基金(No. 20972040);河北省教育厅青年基金(No. Q2012001)和河北工业职业技术学院青年基金(No. Qz1102)资助项目

Synthesis and Antifungal Activity of 2-Carbalkoxyalkyl/(n-butyl)-4-aryl-1,5-benzothiazepines

Li Wenhonga,b, Liu Xiyinga, Zhang Boa, Li Yuana   

  1. a College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050024;
    b Environment and Chemical Engineering, Hebei College of Industry and Technology, Shijiazhuang 050091
  • Received:2013-10-23 Revised:2013-01-18 Published:2013-02-22
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20972040), the Research Project of Education Department of Hebei Province of China (No. Q2012001), and the Scientific Research Fund of Hebei College of Industry and Technology (No. Qz1102).

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A series of novel 2-substituted-1,5-benzothiazepines were synthesized successfully and their structures were determined by elemental analysis, IR, MS/HRMS and 1H NMR. The synthetic conditions of 2-substituted-4-aryl-1,5-benzothiazepines were investigated. The antifungal activities of these 2-substituted-1,5-benzothiazepine derivatives were tested and the results confirmed that the 2-ethyl carboxylate was necessary for antifungal activity in 1,5-benzothiazepine compounds 1.

Key words: 1,5-benzothiazepine, synthesis, antifungal activities, structure-activity relationship