Thioflavin T-Based Fluorescent Probe for Visual Detection of Hg2+

doi:10.6023/cjoc201309001

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (2): 403-408.DOI: 10.6023/cjoc201309001 Previous Articles Next Articles

Notes

基于硫磺素T的可视化检测汞离子的荧光探针

张勇^a,b, 王强^a, 李伟^a, 张静^b, 夏明辉，陈世明^b, 陈雪梅^c

a 湖北理工学院化学与材料工程学院黄石 435003;
b 矿区环境污染控制与修复湖北省重点实验室黄石 435003;
c 黄石市中心医院黄石 435001

收稿日期:2013-09-20 修回日期:2013-10-31 发布日期:2013-11-11
通讯作者: 张勇 E-mail:zy0340907@163.com
基金资助:
湖北省教育厅青年人才（No.Q20134402）、湖北理工学院校级创新人才（No.12xjz21C）和矿区环境污染控制与修复湖北省重点实验室开放基金（No.2012103）资助项目.

Thioflavin T-Based Fluorescent Probe for Visual Detection of Hg²⁺

Zhang Yong^a,b, Wang Qiang^a, Li Wei^a, Zhang Jing^b, Xia Minghui^b, Chen Shiming^c

a School of Chemical and Materials Engineering, Hubei Polytechnic University, Huangshi 435003;
b Hubei Key Laboratory of Mine Environmental Pollution Control & Remediation, Huangshi 435003;
c Huangshi Center Hospital, Huangshi 435001

Received:2013-09-20 Revised:2013-10-31 Published:2013-11-11
Supported by:
Project supported by the Youth Program of Educational Commission of Hubei of China (No. Q20134402), the Hubei Polytechnic University Innovation Program (No. 12xjz21C) and the Open Foundation of Hubei Key Laboratory of Mine Environmental Pollution Control & Remediation (No. 2012103).

A thioflavin T-based fluorescent probe was synthesized by using o-aminobenzenethiol and copper reagent as raw materials. The results showed that it exhibited relatively high sensitivity and selectivity to Hg²⁺, and the common metal ions hardly interfered in the determination. The probe could be used for the visual detection of Hg²⁺ and applied to image intracelluar Hg²⁺ in living Hela cells.

Key words: thioflavin T, mercuric ion, fluorescent probe, fluorescence spectroscopy, visual detection

Cite this article

Zhang Yong, Wang Qiang, Li Wei, Zhang Jing, Xia Minghui, Chen Shiming, Chen Xuemei. Thioflavin T-Based Fluorescent Probe for Visual Detection of Hg²⁺[J]. Chin. J. Org. Chem., 2014, 34(2): 403-408.

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基于硫磺素T的可视化检测汞离子的荧光探针

Thioflavin T-Based Fluorescent Probe for Visual Detection of Hg²⁺

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