Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (3): 495-506.DOI: 10.6023/cjoc201310012 Previous Articles     Next Articles

苯并咪唑类化合物的合成方法进展

朱观明, 杨柳阳, 崔冬梅   

  1. 浙江工业大学药学院 杭州 310014
  • 收稿日期:2013-10-13 修回日期:2013-11-16 发布日期:2013-11-28
  • 通讯作者: 崔冬梅 E-mail:cuidongmei@zjut.edu.cn
  • 基金资助:

    浙江省自然科学基金(No. Y4100558)资助项目.

Advances in the Synthetic Methods of Benzimidazoles

Zhu Guanming, Yang Liuyang, Cui Dongmei   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2013-10-13 Revised:2013-11-16 Published:2013-11-28
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (No. Y4100558).

Benzimidazoles possess various bioactivities, such as anti-HIV-I, antineoplastic, antiproliferation, antiparasitic and so on, hence the synthetic methods of this class of compounds have attracted much attention. In order to provide some inspiration of better synthetic method design, in this review these methods reported during past five years will be firstly classified into three types according to the reaction intermediates, namely N-methene o-diaminobenzene (or N-methene-o-nitroaniline), N-acyl o-diaminobenzenes and arylamidine (aryl guanidine).

Key words: benzimidazole, N-methene o-diaminobenzene, N-methene-o-nitroaniline, N-acyl o-diaminobenzene, aryl amidine (aryl guanidine), catalyst