Direct Amination of N-Acyliminium Ion Surrogates: A Convenient Access to gem-Diamines Derivatives

doi:10.6023/cjoc201410017

Abstract

A novel 4-methylbenzenesulfonic acid (PTSA)-catalyzed intermolecular amination of N-acyliminium species with various N-sources via benzylic C(sp³)-O activation of functionalized 2-oxo-1-pyrrolidine derivatives has been developed. This method provides an efficient and chromatography-free access to gem-diamines equivalent with moderate to good yields. Because of the importance of gem-diamine derivatives, the methodology is expected to have a significant value for practical applications.

Key words: N-acyliminium ion, gem-diamines, green chemistry

Cite this article

Yang Jinming, Chu Xueqiang, Ji Shunjun. Direct Amination of N-Acyliminium Ion Surrogates: A Convenient Access to gem-Diamines Derivatives[J]. Chin. J. Org. Chem., 2014, 34(12): 2462-2470.

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