Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety

doi:10.6023/cjoc201508018

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2617-2623.DOI: 10.6023/cjoc201508018 Previous Articles Next Articles

Notes

新型含取代噻二唑环结构的吡唑肟类化合物的合成及生物活性研究

戴红^a,b, 黄菊华^a, 金智超^a, 成晓燕^a, 黄凯薇^a, 凌勇^c, 汪清民^b, 石玉军^a

a 南通大学化学化工学院南通 226019;
b 南开大学元素有机化学国家重点实验室天津 300071;
c 南通大学药学院南通 226001

收稿日期:2015-08-18 修回日期:2015-09-11 发布日期:2015-09-17
通讯作者: 凌勇, 石玉军 E-mail:zhanghj2801@163.com;yjshi2015@163.com
基金资助:
国家自然科学基金(Nos. 21202089, 21372135)、元素有机化学国家重点实验室开放课题(No. 201412)、江苏省大学生创新训练计划和南通市科技计划(Nos. AS2013004, AS2014011)资助项目.

Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety

Dai Hong^a,b, Huang Juhua^a, Jin Zhichao^a, Cheng Xiaoyan^a, Huang Kaiwei^a, Ling Yong^c, Wang Qingmin^b, Shi Yujun^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
c School of Pharmacy, Nantong University, Nantong 226001

Received:2015-08-18 Revised:2015-09-11 Published:2015-09-17
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province and the Science and Technology Project Fund of Nantong City (Nos. AS2013004, AS2014011).

1. Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety.PDF(892KB)

Abstract

In order to find novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oximes carrying substituted thiadiazole moiety were prepared by the introduction of the key thiadiazole backbone into the molecules of pyrazole oximes. The structures of the title compounds were characterized by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data displayed that some of the title compounds showed good insecticidal activities against Aphis craccivora and Nilaparvata lugens. In addition, some target compounds also exhibited certain larvicidal activity against Oriental armyworm.

Key words: substituted thiadiazole, pyrazole oxime, synthesis, biological activity

Cite this article

Dai Hong, Huang Juhua, Jin Zhichao, Cheng Xiaoyan, Huang Kaiwei, Ling Yong, Wang Qingmin, Shi Yujun. Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety[J]. Chin. J. Org. Chem., 2015, 35(12): 2617-2623.

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新型含取代噻二唑环结构的吡唑肟类化合物的合成及生物活性研究

Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety

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