Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety

doi:10.6023/cjoc201512019

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1431-1437.DOI: 10.6023/cjoc201512019 Previous Articles Next Articles

Notes

新型含氟甲基吡唑结构的氰基丙烯酸酯类化合物的合成及其生物活性

石玉军^a,b, 李阳^a, 方源^a, 叶林玉^b, 陈佳^b, 戴红^b

a 江苏科技大学环境与化学工程学院镇江 212003;
b 南通大学化学化工学院南通 226019

收稿日期:2015-12-14 修回日期:2016-01-07 发布日期:2016-02-02
通讯作者: 石玉军, 戴红 E-mail:yjshi2015@163.com;daihong_2001@aliyun.com
基金资助:
国家自然科学基金(Nos.21202089,21372135)、江苏省“六大人才高峰”(Nos.2011-SWYY-009,2013-SWYY-013)和南通市科技计划(Nos.AS2014011,CP12013002)资助项目.

Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety

Shi Yujun^a,b, Li Yang^a, Fang Yuan^a, Ye Linyu^b, Chen Jia^b, Dai Hong^b

aSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003;
b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received:2015-12-14 Revised:2016-01-07 Published:2016-02-02
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (Nos. 2011-SWYY-009, 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (Nos. AS2014011, CP12013002).

1. Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety.PDF(1057KB)

Abstract

In order to find novel cyanoacrylate lead compounds, 17 new cyanoacrylate compounds bearing fluoride methyl pyrazole moiety were synthesized by the method of active substructure combination. They were structurally confirmed by ¹H NMR, ¹³C NMR and elemental analysis. The structures of compounds 7b, 7f, 7j and 7o were also tested through MS technique. Preliminary bioassay data showed that some of the target compounds displayed important anti-tumor activities.

Key words: fluoride methyl pyrazole, cyanoacrylate, synthesis, biological activity

Cite this article

Shi Yujun, Li Yang, Fang Yuan, Ye Linyu, Chen Jia, Dai Hong. Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety[J]. Chin. J. Org. Chem., 2016, 36(6): 1431-1437.

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新型含氟甲基吡唑结构的氰基丙烯酸酯类化合物的合成及其生物活性

Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety

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