Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles

doi:10.6023/cjoc201511004

Abstract

Ugi/de-Boc/cyclization (UDC) strategy represents a “three-step, one-pot procedure”, employing the Ugi multi-component reaction utilizing one bi-functional group substrates with N-Boc-protected amino, followed by Boc-deprotection and cyclization to synthesize nitrogen-containing heterocycles. This strategy has the characteristics of rapid, efficiency, economy and structural diversity, which can be used to build libraries of complex nitrogen-containing heterocycles and has drawn much attention recently. In this paper, the research progress of UDC strategy in the synthesis of five-, six- and seven-mem- bered heterocycles and natural products were summarized.

Key words: UDC, Ugi reaction, de-Boc group, cyclization, nitrogen-containing heterocycle, synthesis, multi-component reaction

Cite this article

Zhang Zhaorui, Zheng Xiaolin, Guo Changbin. Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles[J]. Chin. J. Org. Chem., 2016, 36(6): 1241-1265.

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Ugi反应脱Boc保护基环合策略在含氮杂环合成中的应用