Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives

doi:10.6023/cjoc201601003

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1382-1388.DOI: 10.6023/cjoc201601003 Previous Articles Next Articles

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钯催化的二甲亚砜对炔酰胺的氧化反应:α-酮酰胺衍生物的高效合成方法

孟团结, 冯翠兰, 刘澜涛, 王涛, 许凯, 赵文献

商丘师范学院化学化工学院药物绿色合成河南省工程实验室商丘 476000

收稿日期:2016-01-03 修回日期:2016-02-04 发布日期:2016-02-18
通讯作者: 刘澜涛, 赵文献 E-mail:liult05@iccas.ac.cn;zhwx2595126@163.com
基金资助:
国家自然科学基金(Nos.U1204204,21172139,21202095)、河南省科技攻关项目(No.142102210635)和河南省高等学校青年骨干教师(No.2015GGJS-126)资助项目.

Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives

Meng Tuanjie, Feng Cuilan, Liu Lantao, Wang Tao, Xu Kai, Zhao Wenxian

Engineering Laboratory of Henan Province for Green Synthesis of Medicine, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000

Received:2016-01-03 Revised:2016-02-04 Published:2016-02-18
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. U1204204, 21172139, 21202095), the Science and Technology Key Project of Henan Province (No. 142102210635), and the Program for University Key Young Teachers of Henan Province (No. 2015GGJS-126).

1. Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives.PDF(768KB)

Abstract

A series of α-ketoamide derivatives were obtained from the palladium catalyzed oxidation of ynamides using cheap and readily available dimethyl sulfoxide as oxidant and solvent under room temperature. The structures of all products were characterized by ¹H NMR, ¹³C NMR, IR and HRMS. This protocol has some distinct advantages of mild conditions, simple work-up, readily available starting materials and fast reaction rate.

Key words: dimethyl sulfoxide, ynamides, α-ketoamides, synthesis, oxidation

Cite this article

Meng Tuanjie, Feng Cuilan, Liu Lantao, Wang Tao, Xu Kai, Zhao Wenxian. Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives[J]. Chin. J. Org. Chem., 2016, 36(6): 1382-1388.

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钯催化的二甲亚砜对炔酰胺的氧化反应:α-酮酰胺衍生物的高效合成方法

Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives

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