Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1948-1953.DOI: 10.6023/cjoc201601032 Previous Articles     Next Articles



许招会a, 周鹏b, 林春花a, 刘德永a   

  1. a 江西师范大学化学化工学院 南昌 330022;
    b 南昌理工学院新能源与环境工程学院 南昌 330029
  • 收稿日期:2016-01-23 修回日期:2016-03-22 发布日期:2016-04-07
  • 通讯作者: 许招会
  • 基金资助:

    国家自然科学基金(No. 20566004)和江西省研究生创新基金(No. YC2015-B023)资助项目.

Efficient One-Pot Synthesis of Diphenyl-2,4-dioxa-8,10-diazaspiro-[5.5]undecane-1,5,9-trione Derivatives under Solvent-Free and Catalyst-Free

Xu Zhaohuia, Zhou Pengb, Lin Chunhuaa, Liu Deyonga   

  1. a Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022;
    b School of New Energy and Enviroment Engineering, Nanchang Institute of Technology, Nanchang 330029
  • Received:2016-01-23 Revised:2016-03-22 Published:2016-04-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20566004) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).

Twelve kinds of diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives were synthesized by the three-component one-pot reaction of aromatic aldehydes with urea and 2,2-butylidene-1,3-dioxane-4,6-dione or 2,2-pentyli- dene-1,3-dioxane-4,6-dione under solvent-free and catalyst-free. The yields ranged from 49% to 63%. Its advantages were no solvent pollution and mild reaction conditions. Furthermore, a proposed reaction mechanism for this condensation reaction was speculated and the relationship between reaction speed and substituent groups was also described. All the compounds synthesized were confirmed by 1H NMR, 13C NMR, ESI-MS and IR techniques.

Key words: three-component reaction, diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives, solvent- free, catalyst-free