Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions

doi:10.6023/cjoc201602001

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1932-1936.DOI: 10.6023/cjoc201602001 Previous Articles Next Articles

NOTE

无催化剂条件下合成喹啉并吡咯并喹啉衍生物

赵群^a, 姚昌盛^b, 王香善^b

a 南京中医药大学药学院南京 210023;
b 江苏师范大学化学化工学院徐州 221116

收稿日期:2016-02-01 修回日期:2016-03-25 发布日期:2016-04-15
通讯作者: 王香善 E-mail:xswang@jsnu.edu.cn
基金资助:
江苏省高校重大基础研究基金（No. 14KJA150004）和江苏省高校优势学科建设工程资助项目.

Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions

Zhao Qun^a, Yao Changsheng^b, Wang Xiangshan^b

a College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023;
b Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received:2016-02-01 Revised:2016-03-25 Published:2016-04-15
Supported by:
Project supported by the Major Natural Science Foundation of Jiangsu Province (No. 14KJA150004), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

1. Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions.PDF(396KB)

Abstract

In this paper, a series of 13-aryl-6,13-dihydro-3H-quino[4,3-b]pyrrolo[3,2-f]quinolin-12(11H)-one derivatives was synthesized in EtOH under catalyst-free conditions using aromatic aldehydes, 5-aminoindole and 4-hydroxyquinolin-2(1H)- one as reactants. The structure of 4b was confirmed by X-ray diffraction analysis. This procedure has the advantages of simplicity and easy operation. An efficient method for the synthesis of fused pentacyclic heterocycles containing biquinolines moieties is provided.

Key words: quinopyrroloquinoline, 5-aminoindole, catalyst-free, synthesis

Cite this article

Zhao Qun, Yao Changsheng, Wang Xiangshan. Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions[J]. Chin. J. Org. Chem., 2016, 36(8): 1932-1936.

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无催化剂条件下合成喹啉并吡咯并喹啉衍生物

Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions

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