Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination

doi:10.6023/cjoc201703012

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2028-2033.DOI: 10.6023/cjoc201703012 Previous Articles Next Articles

ARTICLE

钯催化分子内胺化合成苯并噁嗪酮衍生物

周盼盼^a, 管明玉^a, 张静宇^b,c, 徐凡^a, 赵应声^a

a 苏州大学材料化学化工学部苏州 215123;
b 苏州大学物理与光电学部能源与材料创新研究院苏州 215123;
c 江苏省先进碳材料与可穿戴能源技术重点实验室苏州 215123

收稿日期:2017-03-06 修回日期:2017-04-08 发布日期:2017-04-21
通讯作者: 赵应声 E-mail:yszhao@suda.edu.cn
基金资助:
国家自然科学基金（No.21572149）和国家自然科学青年基金（Nos.21402133，21403148）资助项目.

Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination

Zhou Panpan^a, Guan Mingyu^a, Zhang Jingyu^b,c, Xu Fan^a, Zhao Yingsheng^a

a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123;
b Soochow Institute for Energy and Materials Innovation, College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123;
c Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Suzhou 215123

Received:2017-03-06 Revised:2017-04-08 Published:2017-04-21
Contact: 10.6023/cjoc201703012 E-mail:yszhao@suda.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21572149) and the Young National Natural Science Foundation of China (Nos. 21402133, 21403148).

1. Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination.PDF(4827KB)

Abstract

Benzoxazinone and its derivatives are well-known as a broad-spectrum of physiological activities compounds. Herein we report a novel approach for the synthesis of benzoxazine derivatives via a N,O-bindentate directing assisted Pd-catalyzed intramolecular amination reactions. Various benzoxazinone derivatives are obtained in moderate to good yields. The directing group can be removed under mild condition, highlighting potential synthetic utility of this method.

Key words: C—H functionalization, palladium catalysis, phenoxyacetic acid, intramolecular amination

Cite this article

Zhou Panpan, Guan Mingyu, Zhang Jingyu, Xu Fan, Zhao Yingsheng. Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination[J]. Chin. J. Org. Chem., 2017, 37(8): 2028-2033.

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钯催化分子内胺化合成苯并噁嗪酮衍生物

Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination

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