Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

doi:10.6023/cjoc201708020

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3155-3162.DOI: 10.6023/cjoc201708020 Previous Articles Next Articles

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新型含取代吡唑环结构的吡唑肟醚衍生物的合成及生物活性研究

戴红^a, 姚炜^a, 孙思宇^a, 李玲^a, 施磊^a, 钱宏炜^a, 李春建^b, 石健^b, 石玉军^a

a 南通大学化学化工学院南通 226019;
b 南通大学分析测试中心南通 226019

收稿日期:2017-08-10 修回日期:2017-09-05 发布日期:2017-09-19
通讯作者: 施磊, 石玉军 E-mail:gaohbhe2015@aliyun.com;yjshi2015@163.com
基金资助:
国家自然科学基金（No.21372135）、江苏省“六大人才高峰”（No.2013-SWYY-013）和江苏省研究生实践创新计划（No.SJCX17_0640）资助项目.

Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

Dai Hong^a, Yao Wei^a, Sun Siyu^a, Li Ling^a, Shi Lei^a, Qian Hongwei^a, Li Chunjian^b, Shi Jian^b, Shi Yujun^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b Analysis and Testing Center, Nantong University, Nantong 226019

Received:2017-08-10 Revised:2017-09-05 Published:2017-09-19
Contact: 10.6023/cjoc201708020 E-mail:gaohbhe2015@aliyun.com;yjshi2015@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).

1. Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group.PDF(1031KB)

Abstract

In order to find novel pyrazole oxime ethers with good bioactivities, a series of novel pyrazole oxime ether compounds containing substituted pyrazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were characterized by ¹H NMR,¹³C NMR, and elemental analysis. Preliminary bioassay displayed that most target compounds had good insecticidal activities. At the concentration of 500 μg/mL, sixteen compounds showed insecticidal activity against Oriental armyworm with 80%~100%, fourteen compounds exhibited insecticidal activity against Aphis medicaginis with 80%~100%, and twelve compounds showed insecticidal activity against Nilaparvata lugens with 70%~100%. When the dosage was lowered to 100 μg/mL, five compounds still possessed inhibitory effect against Aphis medicaginis with 50%~80%.

Key words: pyrazole, pyrazole oxime, synthesis, bioactivity

Cite this article

Dai Hong, Yao Wei, Sun Siyu, Li Ling, Shi Lei, Qian Hongwei, Li Chunjian, Shi Jian, Shi Yujun. Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group[J]. Chin. J. Org. Chem., 2017, 37(12): 3155-3162.

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新型含取代吡唑环结构的吡唑肟醚衍生物的合成及生物活性研究

Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

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