Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2450-2457.DOI: 10.6023/cjoc201806030 Previous Articles     Next Articles

Special Issue: 合成科学



石玉军a, 周钱a, 王杨a, 钱宏炜a, 叶林玉a, 冯霞a, 陈辉b, 李雅婷a, 戴红b,a, 魏中昊a, 吴锦明a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通大学杏林学院 南通 226008
  • 收稿日期:2018-06-20 修回日期:2018-07-19 发布日期:2018-08-14
  • 通讯作者: 戴红, 吴锦明;
  • 基金资助:


Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Pyridyl Group

Shi Yujuna, Zhou Qiana, Wang Yanga, Qian Hongweia, Ye Linyua, Feng Xiaa, Chen Huib, Li Yatinga, Dai Hongb,a, Wei Zhonghaoa, Wu Jinminga   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b Xinglin College, Nantong University, Nantong 226008
  • Received:2018-06-20 Revised:2018-07-19 Published:2018-08-14
  • Contact: 10.6023/cjoc201806030;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201810304016Z) and the Science Foudation of Nantong University Xinglin College (No. 2016K130).

In order to find novel pyrazole amides having potent bioactivities, a series of novel pyrazole amide compounds carrying substituted pyridyl moiety were designed and synthesized according to the method of active substructure combination. The preliminary bioassay data showed that some title compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 60%~100%, and one compound indicated insecticidal activity against Aphis medicaginis with 100%. When the concentration was reduced to 100 μg/mL, two compounds still showed insecticidal activity against Oriental armyworm with 70%~100%, which were better than that of the control tolfenpyrad. Additionally, one compound displayed 50% insecticidal activity against Oriental armyworm at the concentration of 20 μg/mL.

Key words: pyridine, pyrazole amide, synthesis, bioactivity