Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

doi:10.6023/cjoc201801040

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2784-2790.DOI: 10.6023/cjoc201801040 Previous Articles Next Articles

Notes

含苯并噻唑的硫脲嘧啶衍生物的合成及抗菌活性评价

崔朋雷^a,b, 刘娜^a, 陈华^a, 李小六^a

a 河北大学化学与环境科学学院河北省化学生物学重点实验室保定 071002;
b 河北农业大学理学院保定 071001

收稿日期:2018-01-27 修回日期:2018-03-19 发布日期:2018-06-01
通讯作者: 陈华,E-mail:hua-todd@163.com E-mail:hua-todd@163.com
基金资助:
河北农业大学理工基金（No.LG20150503）资助项目.

Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

Cui Penglei^a,b, Liu Na^a, Chen Hua^a, Li Xiaoliu^a

a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
b College of Science, Agricultural University of Hebei, Baoding 071001

Received:2018-01-27 Revised:2018-03-19 Published:2018-06-01
Contact: 10.6023/cjoc201801040 E-mail:hua-todd@163.com
Supported by:
Project supported by the Science and Technology Fund of Agricultural University of Hebei (No. LG20150503)

1. Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole.PDF(1673KB)

Abstract

A series of unreported thiouracil derivatives 7 containing a benzothiazole moiety were synthesized by the reaction of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (6) with N-(benzo[d]thiazol-2-yl)-4-(chloromethyl)-benzamide (5), which was prepared from the amidation of 2-aminobenzothiazole and 4-(chloromethyl)benzoyl chloride. The newly synthesized compounds 7 were characterized by IR, MS, NMR, and element analysis. All the compounds were evaluated for their antibacterial activities against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis. The results of the 24-hour antibacterial test showed that some compounds had good inhibitory activities against the three tested strains.

Key words: thiouracil, benzothiazole, antibacterial activity

Cite this article

Cui Penglei, Liu Na, Chen Hua, Li Xiaoliu. Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole[J]. Chin. J. Org. Chem., 2018, 38(10): 2784-2790.

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含苯并噻唑的硫脲嘧啶衍生物的合成及抗菌活性评价

Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

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