Research Progress of Rhamnosyltransferase

doi:10.6023/cjoc201806004

Abstract

Rhamnosylation is an important type of glycosylation reaction which is widely involved in organic synthesis and structural modification of natural products. In vivo, rhamnosylation is catalyzed by rhamnosyltransferase that transferred the active rhamnosyl donors to the specific sugar acceptors. A larger number of rhamnosyltransferases have been identified in natural and they often played key roles in the biosynthesis of diverse natural products as well as maintaining the cell structure and physiological functions of biological organisms. Besides, enzymatic rhamnosylation has been an effective complementary method to chemical catalysis in the field of organic glycosylation modifications due to its high catalysis efficiency and specificity, mild reaction conditions as well as environment friendship and so on. In this article, research progresses of rhamnosyltransferase are reviewed based on their enzymatic functions, three dimensional structure investigations, rhamnosyl donors' synthesis, enzymatic catalysis promiscuities, and biochemical catalysis applications. Finally, the future development and application of them are also prospected.

Key words: rhamnosyltransferase, biosynthesis, enzyme catalysis, biocatalysis

Cite this article

Yan Yaru, Qi Bowen, Mo Ting, Wang Xiaohui, Wang Juan, Shi Shepo, Liu Xiao, Tu Pengfei. Research Progress of Rhamnosyltransferase[J]. Chin. J. Org. Chem., 2018, 38(9): 2281-2295.

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