Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes

doi:10.6023/cjoc201805022

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3211-3218.DOI: 10.6023/cjoc201805022 Previous Articles Next Articles

Special Issue: 碳氢活化合辑2018-2019

Articles

钌(Ⅲ)催化的芳烃室温邻位羟甲基化反应

张勇, 杨中振, 余昕玲, 程旭, 李伟剑, 郭令妹, 海俐, 郭丽, 吴勇

四川大学华西药学院成都 610041

收稿日期:2018-05-09 修回日期:2018-07-31 发布日期:2018-09-05
通讯作者: 郭丽, 吴勇 E-mail:guoli@scu.edu.cn;wyong@scu.edu.cn
基金资助:
国家自然科学基金（Nos.81373259，81573286，81602954）资助项目.

Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes

Zhang Yong, Yang Zhongzhen, Yu Xinling, Cheng Xu, Li Weijian, Guo Lingmei, Hai Li, Guo Li, Wu Yong

Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041

Received:2018-05-09 Revised:2018-07-31 Published:2018-09-05
Contact: 10.6023/cjoc201805022 E-mail:guoli@scu.edu.cn;wyong@scu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286, 81602954).

1. Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes.PDF(1802KB)

Abstract

Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(Ⅲ)-catalyzed nitrogen atom directed C-H activation is described. The reaction proceeds smoothly at room temperature and generates the corresponding products in moderate to excellent yields. Meanwhile, it has a broad substrate scope and opens up an attractive avenue for the application of direct hydroxymethylation in the synthesis of biologically active compounds.

Key words: C-H activation, paraformaldehyde, hydroxymethylation, room temperature

Cite this article

Zhang Yong, Yang Zhongzhen, Yu Xinling, Cheng Xu, Li Weijian, Guo Lingmei, Hai Li, Guo Li, Wu Yong. Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes[J]. Chin. J. Org. Chem., 2018, 38(12): 3211-3218.

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钌(Ⅲ)催化的芳烃室温邻位羟甲基化反应

Room Temperature Ru(Ⅲ)-Catalyzed ortho-Hydroxymethylation of Arenes

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