Recent Developments in Protein Engineering and Catalytic Oxidations of Baeyer-Villiger Monooxygenase

doi:10.6023/cjoc201810023

Abstract

Baeyer-Villiger monooxygenase (BVMO) is an important biocatalyst for Baeyer-Villiger oxidation of various organic ketone/aldehyde compounds, and sulfur, selenium, or boron-containing heteroatoms compounds. As an indispensable tool, BVMO-catalyzed oxidation displays some advantages, such as high selectivity, mild reaction conditions and high efficiency, leading to wide applications into the synthesis of chiral compounds. In recent years, bioinformatics analysis and genome mining have been used to find more novel BVMOs from microorganisms. Besides natural substrates, these BVMOs can accept various organic compounds showing wide substrate scope. Meanwhile, protein engineering has been widely used to improve the catalytic performance of BVMOs, such as the expanded substrate scope, high thermostability and activity, high stereo-, regio-and chemo-selectivities. Based on the Baeyer-Villiger oxidation reaction with different substrate structures, the recent advancements in the research on the catalytic oxidation of wild type and protein-engineered BVMOs in the past five years are summarized.

Key words: Baeyer-Villiger monooxygenase, Baeyer-Villiger oxidation, biocatalysis, asymmetric synthesis, protein engineering

Cite this article

Zheng He, Zhou Yuke, Lin Xianfu, Wu Qi. Recent Developments in Protein Engineering and Catalytic Oxidations of Baeyer-Villiger Monooxygenase[J]. Chin. J. Org. Chem., 2019, 39(4): 903-915.

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