Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1772-1778.DOI: 10.6023/cjoc202001028 Previous Articles     Next Articles


张敏a, 郑丹丹a, 倪亚丹a, 梁凯a, 荀校a, 胡兰萍a, 陈庆文a, 杨冰a, 梁志鹏b, 丁颖a, 石健b, 戴红a   

  1. a 南通大学化学化工学院 江苏南通 226019;
    b 南通大学分析测试中心 江苏南通 226019
  • 收稿日期:2020-01-20 修回日期:2020-02-27 发布日期:2020-03-06
  • 通讯作者: 胡兰萍, 杨冰, 戴红;;
  • 基金资助:

Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety

Zhang Mina, Zheng Dandana, Ni Yadana, Liang Kaia, Xun Xiaoa, Hu Lanpinga, Chen Qingwena, Yang Binga, Liang Zhipengb, Ding Yinga, Shi Jianb, Dai Honga   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangshu 226019;
    b Analysis and Testing Center, Nantong University, Nantong, Jiangshu 226019
  • Received:2020-01-20 Revised:2020-02-27 Published:2020-03-06
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21372135) and the Science and Technology Project Fund of Nantong City (No. MS12019060).

In order to find new pyrazole amides with wonderful bioactivities, a series of novel pyrazole amide derivatives were synthesized by introducing substituted oxazole ring into the C-5 position of pyrazole skeleton based on the lead chlorantraniliprole. The aimed compounds were structurally characterized through 1H NMR, 13C NMR and elemental analysis. The preliminary bioassay results exhibited that all the title compounds displayed more than 90% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL. At the dosage of 100 μg/mL, five compounds possessed 90%~100% insecticidal activities against Mythimna separata (Walker), and three compounds exhibited insecticidal property against Aphis craccivora with 90%~100%. Additionally, at the dosage of 500 μg/mL, two compounds possessed insecticidal activity against Tetranychus cinnabarinus with 80%~100%.

Key words: oxazole, pyrazole amide, synthesis, bioactivity