Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3463-3466.DOI: 10.6023/cjoc202005085 Previous Articles     Next Articles

Special Issue: 有机硅化学虚拟合辑 黄乃正院士七十华诞专辑


王子超a,b, 许佑君b, 施世良a   

  1. a 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032;
    b 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室 沈阳 110016
  • 收稿日期:2020-05-29 修回日期:2020-07-03 发布日期:2020-07-23
  • 通讯作者: 许佑君, 施世良;
  • 基金资助:

Base-Promoted Rapid Hydrosilylation of Aldimine

Wang Zichaoa,b, Xu Youjunb, Shi Shilianga   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032;
    b Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Shenyang 110016
  • Received:2020-05-29 Revised:2020-07-03 Published:2020-07-23
  • Supported by:
    Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000) and the National Natural Science Foundation of China (Nos. 21690074, 21871288, 91856111, 21821002).

Amines are important intermediates in organic synthesis. The hydrosilylation of imines provides a convenient method for the synthesis of amines. Transition metal and main group catalysts have been widely applied in the hydrosilylation of imines. However, it would be more practical to use simpler reaction conditions to realize such reactions. In this paper, a fast hydrosilylation of aldimine was realized by using cheap t-BuOK as the promoter, providing an efficient method for the synthesis of amines in high yield. This reaction features rapid reaction, facile conditions, and robust practicability.

Key words: hydrosilylation, aldimine, rapid reaction, base catalysis