Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 1789-1803.DOI: 10.6023/cjoc202011005 Previous Articles     Next Articles

REVIEWS

三氟乙基酮亚胺参与的催化不对称反应研究进展

孙忠文1,*(), 张聪聪1, 陈丽君1, 谢惠定1, 柳波1, 刘丹丹1,*()   

  1. 1 昆明医科大学药学院 云南省天然药物药理重点实验室 昆明 650500
  • 收稿日期:2020-11-04 修回日期:2020-12-10 发布日期:2020-12-31
  • 通讯作者: 孙忠文, 刘丹丹
  • 基金资助:
    国家自然科学基金(21907044); 云南省基础研究计划项目(2019FB124); 云南省科技厅-昆明医科大学应用基础研究联合专项基金项目(2017FE468(-138)); 云南省教育厅科学研究基金(2016ZZX089); 西南林业大学西南地区林业生物质高效利用国家林和草原局重点实验室开放基金(2019-KF18); 西南林业大学西南地区林业生物质高效利用国家林和草原局重点实验室开放基金(2020-KF06)

Recent Advances in Catalytic Asymmetric Reactions Involving Trifluoroethyl Ketimines

Zhongwen Sun1,*(), Congcong Zhang1, Lijun Chen1, Huiding Xie1, Bo Liu1, Dandan Liu1,*()   

  1. 1 School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500
  • Received:2020-11-04 Revised:2020-12-10 Published:2020-12-31
  • Contact: Zhongwen Sun, Dandan Liu
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21907044); Yunnan Fundamental Research Projects(2019FB124); Yunnan Provincial Science and Technology Department-Kunming Medical University Applied Basic Research Joint Special Fund Project(2017FE468(-138)); Yunnan Provincial Department of Education Science Research Fund Project(2016ZZX089); Open Fund of Key Laboratory of State Forestry and Grassland Adminstration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University(2019-KF18); Open Fund of Key Laboratory of State Forestry and Grassland Adminstration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University(2020-KF06)

The fluorine atoms or fluorine-containing groups are widely found in biologically molecules in the fields of materials science, pharmaceutical chemistry, etc. The properties of trifluoroethylketimines provide both electrophilic and nucleophilic centers, and become an excellent 1,3-dipole, which possessed high research value in catalytic asymmetric reactions of construction of trifluoromethyl stereocenters. Based on the substrates and reaction types of trifluoroethylketimine, the research progress of catalytic asymmetric reactions involving trifluoroethylketimine in recent five years is reviewed, and the future development of this field is prospected.

Key words: trifluoroethylketimine, asymmetric catalysis, cycloaddition, trifluoromethyl group, synthesis of chiral amine