Research Progress of Sulfur Dioxide Fluorescent Probe Targeting Mitochondria

doi:10.6023/cjoc202210030

Abstract

Content of abstract sulfur dioxide (SO₂) is associated with many physiological and pathological processes in living systems, and excessive SO₂ can lead to a series of physiological diseases. Therefore, effective identification and detection of SO₂ have significant application value. Recently, many fluorescent probes for the detection of SO₂ in biological systems have been reported. Compared with traditional detection methods, fluorescent probe has the advantages of high sensitivity, non-invasive detection and real-time imaging. More importantly, the use of fluorescent probes allows visual detection of SO₂ both in vitro and in vivo. Based on different reaction mechanism, the research progress of mitochondrial targeted SO₂ fluorescent probes in the past five years is reviewed, and the challenges and development directions in this field are discussed.

Key words: mitochondria, fluorescent probe, sulfur dioxide, cell imaging

Cite this article

Yifang Li, Yao Wang, Huawei Niu, Xiujin Chen, Zhaozhou Li, Yongguo Wang. Research Progress of Sulfur Dioxide Fluorescent Probe Targeting Mitochondria[J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 1952-1962.

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Probe	LOD	Examination range	Response time
1	13.1 nmol/L	10~100 µmol/L	60 s
2	17 nmol/L	0~7 mmol/L	—^a
3	18.1 nmol/L	0~100 µmol/L	100 s
4	24 nmol/L	0~20 µmol/L	6 s
5	0.46 µmol/L	3.13~200 µmol/L	Within 30 min

Probe	LOD	Examination range	Response time
1	13.1 nmol/L	10~100 µmol/L	60 s
2	17 nmol/L	0~7 mmol/L	—^a
3	18.1 nmol/L	0~100 µmol/L	100 s
4	24 nmol/L	0~20 µmol/L	6 s
5	0.46 µmol/L	3.13~200 µmol/L	Within 30 min

Probe	LOD	Examination range	Response time
6	16 nmol/L	1.5~22.5 µmol/L	2 min
7	30 nmol/L	0~0.6 equiv.	—^a
8	15.6 nmol/L	0~2.5 µmol/L	13 min
9	0.37 µmol/L	0.01~0.15 mmol/L	—^a
10	85 nmol/L	0~3 equiv.	20 s
11	0.066 mmol/L/ 0.079 mmol/L	0~15 μmol/L/ 2~30 μmol/L	5 min
12	0.21 μmol/L	0~50 μmol/L	2 min
13	0.09 μmol/L	0~400 μmol/L	—^a
14	0.57 µmol/L	—^a	150 s
15	0.17 µmol/L	0~5 µmol/L	30 s
16	138 nmol/L	0~10 µmol/L	15 min
17	4.13 nmol/L	15~45 µmol/L	300 s

Probe	LOD	Examination range	Response time
6	16 nmol/L	1.5~22.5 µmol/L	2 min
7	30 nmol/L	0~0.6 equiv.	—^a
8	15.6 nmol/L	0~2.5 µmol/L	13 min
9	0.37 µmol/L	0.01~0.15 mmol/L	—^a
10	85 nmol/L	0~3 equiv.	20 s
11	0.066 mmol/L/ 0.079 mmol/L	0~15 μmol/L/ 2~30 μmol/L	5 min
12	0.21 μmol/L	0~50 μmol/L	2 min
13	0.09 μmol/L	0~400 μmol/L	—^a
14	0.57 µmol/L	—^a	150 s
15	0.17 µmol/L	0~5 µmol/L	30 s
16	138 nmol/L	0~10 µmol/L	15 min
17	4.13 nmol/L	15~45 µmol/L	300 s

Probe	LOD	Examination range	Response time
18	43 nmol/L	0~90 µmol/L	10 s
19	46 nmol/L	0~0.5 µmol/L	—^a
20	2 nmol/L	—^a	60 s
21	26.7 nmol/L	1~4 µmol/L	2 min
22	0.04 µmol/L	0~6 µmol/L	7 min
23	0.0126 µmol/L	—^a	35 s

线粒体靶向的二氧化硫荧光探针研究进展