Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy

doi:10.6023/cjoc202403058

Abstract

Cancer is a leading cause of death globally with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, no drug resistance, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.

Key words: aggregation-induced emission, photodynamics therapy, photothermal therapy, multimodal combination therapy

Cite this article

Zixiang Meng, Xiumei Tian, Tianfu Zhang. Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2441-2452.

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Fig. & Tab. 16

Figure 1. Preparation of TPETCAQ nanoparticles

Figure 2. Structures of four molecules CPy, CQu, DCPy, and DCQu

Figure 3. Decomposition of ABDA under illumination in the presence of different PSs

Figure 4. Structures of three molecules TPS-0, TPS-1, and TPS-2

Figure 5. Molecular structure of TATIC and its photodynamic properties

Figure 6. Structures of α-TPA-PIO and β-TPA-PIO

Figure 7. P1 polymer and its quantum yield

Figure 8. Structure of PTPEAQ polymer

Figure 9. Structures of CP1~CP4

Figure 10. Structure of IR-797 and its photothermal imaging

Figure 11. Structure of BPBBT and its photothermal property

Figure 12. Structure of BBT-C6T-DPA(OMe) and its photothermal property

Figure 13. Application of NIRb14 in PA imaging

Figure 14. Preparation of TTPY-Py and its application in PAI collaborative PDT-PTT

Figure 15. Preparation of TISSI and its multifunctional phototherapy application

Figure 16. Structure of DDTB and its applications in multifunctional surgery and phototherapy

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