有机化学 ›› 2016, Vol. 36 ›› Issue (7): 1447-1464.DOI: 10.6023/cjoc201603030 上一篇    下一篇

综述与进展

Leuconolam-Leuconoxine-Mersicarpine系列单萜吲哚生物碱的全合成研究进展

耿谦a, 李子宁a, 吕哲a, 梁广鑫a,b   

  1. a. 南开大学 元素有机化学国家重点实验室 天津 300071;
    b. 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2016-03-17 修回日期:2016-04-27 发布日期:2016-05-06
  • 通讯作者: 梁广鑫 E-mail:lianggx@nankai.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21372127,21572104)和教育部新世纪人才资助项目.

Progress in Total Syntheses of Leuconolam- Leuconoxine-Mersicarpine Alkaloids

Geng Qiana, Li Zininga, Lü Zhea, Liang Guangxina,b   

  1. a. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2016-03-17 Revised:2016-04-27 Published:2016-05-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372127, 21572104) and the Program for New Century Excellent Talents in University.

Leuconolam-leuconoxine-mersicarpine生物碱是一类主要从夹竹桃科蕊木属植物中分离得到、相互之间具有生源关系的单萜吲哚生物碱,展现出丰富的结构复杂性和多样性. 这类吲哚生物碱的大多数成员都具有抗炎症、抗肿瘤等显著的生物活性. 综述了国内外有机合成化学家对该类天然产物的全合成研究进展.

关键词: leuconolam, leuconoxine, mersicarpine, 吲哚生物碱, 全合成

Leuconolam-leuconoxine-mersicarpine monoterpene indole alkaloids are mainly isolated from Apocynaceae Kopsia species of plant. Though sharing the same biogenetic origin, they are a family of natural products showing incredible structural complexity and diversity. Moreover, many of them exhibit excellent bioactivities, for example, anti-inflammatory, anti-tumor activities. The progress in the total synthesis of this remarkable family of alkaloids is reviewed.

Key words: leuconolam, leuconoxine, mersicarpine, monoterpene indole alkaloid, total synthesis