有机化学 ›› 2019, Vol. 39 ›› Issue (2): 350-362.DOI: 10.6023/cjoc201806038 上一篇    下一篇

所属专题: 镍催化有机反应合辑

综述与进展

镍催化还原偶联反应构筑C(sp2)-C(sp2)/C(sp2)-C(sp3)键的研究进展

李娅琼, 范玉航, 贾乾发   

  1. 长江师范学院化学化工学院 重庆 408100
  • 收稿日期:2018-06-24 修回日期:2018-07-30 发布日期:2018-09-10
  • 通讯作者: 贾乾发 E-mail:li_ychem@yznu.cn
  • 基金资助:

    长江师范学院科研(No.2017KYQD24)资助项目.

Recent Advance in Ni-Catalyzed Reductive Cross-Coupling to Construct C(sp2)-C(sp2) and C(sp2)-C(sp3) Bonds

Li Yaqiong, Fan Yuhang, Jia Qianfa   

  1. College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100
  • Received:2018-06-24 Revised:2018-07-30 Published:2018-09-10
  • Contact: 10.6023/cjoc201806038 E-mail:li_ychem@yznu.cn
  • Supported by:

    Project supported by the Yangtze Normal University (No. 2017KYQD24).

亲电试剂的还原偶联反应避免了有机金属试剂的制备与使用,对各类官能团拥有极好的兼容性,为C-C键的构筑提供了一类重要的方法.近些年来,该反应的研究取得了突破性进展,实现了一系列C(sp2)-X与C(sp3)-X亲电试剂参与的交叉偶联反应.主要针对镍催化亲电试剂交叉偶联反应构筑C(sp2)-C(sp2)和C(sp2)-C(sp3)键的研究展开综述,详细介绍了各种偶联反应及其反应机制.

关键词: 偶联反应, 还原偶联, 亲电试剂, Ni催化

The cross-coupling of two electrophiles has emerged as an important and attractive method for carbon-carbon bond formation. This synthetic protocol avoids preparation of organometallic nucleophilic reagents and exhibits excellent functional group tolerance. Recently, breakthrough progress has been developed to the cross-electrophile coupling of C(sp2)-X/C(sp3)-X. The recent progress in the research of Ni-catalyzed electrophilic coupling for the construction of C(sp2)-C(sp2) and C(sp2)-C(sp3) is reviewed.

Key words: cross-coupling reaction, reductive coupling, electrophiles, Ni catalysis