有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3452-3462.DOI: 10.6023/cjoc202003005 上一篇    下一篇

所属专题: 黄乃正院士七十华诞专辑

研究论文

方酰胺催化氮杂二烯和吡唑啉-5-酮的加成:含吡唑三芳基甲烷的不对称合成

谢焕平b, 吴波b, 陈木旺b, 余长斌b, 黎红旺b, 李翔a, 周永贵a,b   

  1. a 大连理工大学张大煜学院 大连 116024;
    b 中国科学院大连化学物理研究所催化基础国家重点实验室 大连 116023
  • 收稿日期:2020-03-03 修回日期:2020-03-27 发布日期:2020-04-13
  • 通讯作者: 周永贵 E-mail:ygzhou@dicp.ac.cn
  • 基金资助:
    国家自然科学基金(No.21690074)资助项目.

Enantioselective Synthesis of Triarylmethanes Bearing Pyrazole Moiety through Squaramide-Catalyzed Addition of Azadienes with Pyrazolin-5-ones

Xie Huanpingb, Wu Bob, Chen Muwangb, Yu Changbinb, Li Hongwangb, Li Xianga, Zhou Yongguia,b   

  1. a Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024;
    b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023
  • Received:2020-03-03 Revised:2020-03-27 Published:2020-04-13
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21690074).

用金鸡纳碱衍生的手性双功能有机催化剂,实现了橙酮衍生的氮杂二烯和吡唑啉-5-酮的高对映选择性加成反应,最高对映选择性可达99%.该方法学为含吡唑手性三芳基甲烷衍生物合成提供一条简洁的途径.

关键词: 三芳基甲烷, 吡唑, 有机催化, 氮杂二烯, 对映选择性加成

Using cinchona-derived bifunctional squaramides as catalyst, an asymmetric addition of aurone-derived azadienes with pyrazolin-5-ones was developed, providing a series of chiral triarylmethanes bearing pyrazole moiety with up to 99% ee.

Key words: triarylmethane, pyrazole, organocatalysis, azadiene, enantioselective addition