烯丙基肟的环化反应合成异噁唑啉衍生物的研究进展

doi:10.6023/cjoc202003056

摘要/Abstract

异噁唑啉是一类具有诸多生物学特性的杂环，是许多天然产物和生物活性化合物的关键结构骨架，有效的异噁唑啉合成方法已成为广泛的研究主题.描述了利用烯丙基肟合成各种官能化异噁唑啉的最新研究进展，其涉及在氧化剂存在下的自由基氧化/环化反应.这些反应通常使用容易获得的氧化剂和不同的金属或无金属作为催化剂，在中性反应条件下进行反应.

关键词: 异噁唑啉, 烯丙基肟, 环化反应, 金属催化

Isoxazoline is an important class of heterocyclic ring with a wide range of biological characteristics, which is the key structural framework of many natural products and bioactive compounds. The effective synthetic method of isoxazoline has been the subject of extensive research. In this review, the latest progress in the synthesis of various functionalized isoxazoline by allyl oxime, involving the radical oxidation/cyclization reaction in the presence of oxidants is described. These reactions are usually carried out under neutral conditions using readily available oxidants and different metals or metal-free catalysis.

Key words: isoxazoline, allyl oxime, cyclization reaction, metal catalysis

引用此文

刘颖杰, 孟建萍, 李晨, 林立青, 许颖. 烯丙基肟的环化反应合成异噁唑啉衍生物的研究进展[J]. 有机化学, 2020, 40(9): 2742-2754.

Liu Yingjie, Meng Jianping, Li Chen, Lin Liqing, Xu Ying. Progress in the Synthesis of Isoxazoline Derivatives by Cycloylation of Allyl Oxime[J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2742-2754.

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