有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3463-3466.DOI: 10.6023/cjoc202005085 上一篇    下一篇

所属专题: 有机硅化学合辑

研究简报

碱促进醛亚胺的快速氢硅化反应

王子超a,b, 许佑君b, 施世良a   

  1. a 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032;
    b 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室 沈阳 110016
  • 收稿日期:2020-05-29 修回日期:2020-07-03 发布日期:2020-07-23
  • 通讯作者: 许佑君, 施世良 E-mail:shiliangshi@sioc.ac.cn;xuyoujun@syphu.edu.cn
  • 基金资助:
    中国科学院战略性先导科技专项(No.XDB20000000)和国家自然科学基金(Nos.21690074,21871288,91856111,21821002)资助项目.

Base-Promoted Rapid Hydrosilylation of Aldimine

Wang Zichaoa,b, Xu Youjunb, Shi Shilianga   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032;
    b Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Shenyang 110016
  • Received:2020-05-29 Revised:2020-07-03 Published:2020-07-23
  • Supported by:
    Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000) and the National Natural Science Foundation of China (Nos. 21690074, 21871288, 91856111, 21821002).

胺类化合物是一类重要的合成中间体,亚胺的氢硅化反应为胺类化合物的合成提供了一种便利的方法.过渡金属及主族元素催化剂在亚胺氢硅化反应中得到了广泛应用,然而,采用更加简单的反应条件实现这类反应更加具有实用价值.利用廉价易得的叔丁醇钾作为促进剂,实现了醛亚胺的快速还原反应,以良好的收率高效合成了一系列胺类化合物.该反应体系具有反应迅速,条件简单,实用高效的优点.

关键词: 氢硅化反应, 醛亚胺, 快速反应, 碱催化

Amines are important intermediates in organic synthesis. The hydrosilylation of imines provides a convenient method for the synthesis of amines. Transition metal and main group catalysts have been widely applied in the hydrosilylation of imines. However, it would be more practical to use simpler reaction conditions to realize such reactions. In this paper, a fast hydrosilylation of aldimine was realized by using cheap t-BuOK as the promoter, providing an efficient method for the synthesis of amines in high yield. This reaction features rapid reaction, facile conditions, and robust practicability.

Key words: hydrosilylation, aldimine, rapid reaction, base catalysis