方酰胺催化氮杂二烯和吡唑啉-5-酮的加成:含吡唑三芳基甲烷的不对称合成

doi:10.6023/cjoc202003005

摘要/Abstract

用金鸡纳碱衍生的手性双功能有机催化剂，实现了橙酮衍生的氮杂二烯和吡唑啉-5-酮的高对映选择性加成反应，最高对映选择性可达99%.该方法学为含吡唑手性三芳基甲烷衍生物合成提供一条简洁的途径.

Using cinchona-derived bifunctional squaramides as catalyst, an asymmetric addition of aurone-derived azadienes with pyrazolin-5-ones was developed, providing a series of chiral triarylmethanes bearing pyrazole moiety with up to 99% ee.

Key words: triarylmethane, pyrazole, organocatalysis, azadiene, enantioselective addition

引用此文

谢焕平, 吴波, 陈木旺, 余长斌, 黎红旺, 李翔, 周永贵. 方酰胺催化氮杂二烯和吡唑啉-5-酮的加成:含吡唑三芳基甲烷的不对称合成[J]. 有机化学, 2020, 40(10): 3452-3462.

Xie Huanping, Wu Bo, Chen Muwang, Yu Changbin, Li Hongwang, Li Xiang, Zhou Yonggui. Enantioselective Synthesis of Triarylmethanes Bearing Pyrazole Moiety through Squaramide-Catalyzed Addition of Azadienes with Pyrazolin-5-ones[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3452-3462.

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