有机化学 ›› 1983, Vol. 3 ›› Issue (6): 405-416.    下一篇

研究论文

分子内环加成的甾体全合成

庄治平;周维善   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1983-12-25

Total synthesis of steroids through intramolecular cycloaddition

ZHUANG ZHIPING;ZHOU WEISHAN   

  • Published:1983-12-25

关键词: 甾族化合物, 环加成反应, 立体选择性, 旋光性

This paper reviews the recent developments in intramolecular cycloaddition reaction widely used in total synthesis of steroidal compounds. The key step of this method is regiospecific and stereoselective cycloaddition of substituted o-quinodimethanes derived in situ from the corresponding benzocyclobutenes. A large number of estrane and pregnane type steroids as well as optically active steroids have been synthesized by this method recently.

Key words: STEROIDS, CYCLOADDITION REACTION, STEREOSELECTIVITY, OPTICAL ROTATION

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