α,β-不饱和羰基化合物的不对称Diels-Alder反应研究进展

doi:10.6023/cjoc201601027

摘要/Abstract

Diels-Alder反应是典型的[4+2]环合反应，自被发现以来备受化学家们的重视. 不对称Diels-Alder反应是合成手性中间体的有效手段，在手性药物和天然产物全合成中得到广泛应用. α，β-不饱和羰基化合物是有机合成反应的关键中间体，根据其结构特点和催化体系类型，分类阐述了α，β-不饱和羰基化合物为亲双烯体的不对称正电子需求Diels-Alder反应的研究进展.

关键词: 不对称Diels-Alder反应, 天然产物, 有机合成反应, α,β-不饱和羰基化合物

Diels-Alder reaction is a [4+2] concerted cycloaddition reaction, which has attracted considerable attention since its discovery. Asymmetric Diels-Alder reaction is an effective method for synthesis of chiral intermediates, so it was widely applied in the total synthesis of drugs and natural products. α,β-Unsaturated carbonyl compounds are a kind of highly reactive versatile intermediates in organic synthesis, according to its structural characteristics and catalytic types, recent advances in asymmetric normal electron-demand Diels-Alder reaction of α,β-unsaturated carbonyl compounds are reviewed in this paper.

Key words: asymmetric Diels-Alder reaction, natural product, organic synthesis, α,β-unsaturated carbonyl compounds

引用此文

刘文香, 吴宇强, 李灵芝, 李霞. α,β-不饱和羰基化合物的不对称Diels-Alder反应研究进展[J]. 有机化学, 2016, 36(7): 1501-1512.

Liu Wenxiang, Wu Yuqiang, Li Lingzhi, Li Xia. Progress on the Asymmetric Diels-Alder Reaction of α,β-Unsaturated Carbonyl Compounds[J]. Chin. J. Org. Chem., 2016, 36(7): 1501-1512.

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