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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (08): 1034-1037. 上一篇    

研究简报

微波辐射下FeCl3•6H2O催化绿色合成3,4-二氢嘧啶-2-酮

王东超，袁腾飞，杨西宁，渠桂荣*   

  1. (河南师范大学化学与环境科学学院 新乡 453007)
  • 收稿日期:2006-11-23 修回日期:1900-01-01 发布日期:2007-07-30
  • 通讯作者: 渠桂荣*

Microwave-Assisted Green Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Ferric Chloride Hexahydrate

WANG Dong-Chao, YUAN Teng-Fei, YANG Xi-Ning, QU Gui-Rong*   

  1. (College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
  • Received:2006-11-23 Revised:1900-01-01 Published:2007-07-30
  • Contact: QU Gui-Rong*

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在微波辐射下, 仅以六水合三氯化铁为催化剂, 将芳香醛、β-二羰基化合物和脲(物质的量比为1∶1.5∶1.5)在无水乙醇中回流, 高效地合成了3,4-二氢嘧啶-2-酮, 反应时间4～6 min, 操作简便, 环境友好.

关键词: Biginelli反应, 3,4-二氢嘧啶-2-酮, 微波辐射, 六水合三氯化铁

A novel synthesis of 3,4-dihydropyrimidin-2(1H)-ones by a one-pot cyclocondensation of aldehydes, β-dicarbonyl compound and urea (molar ratio 1∶1.5∶1.5) in ethanol, using ferric chloride hexahydrate as a catalyst under microwave irradiation, was described. This method not only has the adventages of short reaction time (4～6 min) and simple operation, but also is environmentally friendly.

Key words: microwave irradiation, 3,4-dihydropyrimidin-2(1H)-one, ferric chloride hexahydrate, Biginelli reaction