有机化学 ›› 2006, Vol. 26 ›› Issue (08): 1136-1139. 上一篇    下一篇

研究简报

O,O'-二烷基-α-(4-三氟甲基苯基)氨基-取代苯基甲基膦酸酯的绿色合成研究

万琼琼,宋宝安*,张国平,金林红
胡德禹,杨松,刘刚   

  1. (贵州大学精细化工研究开发中心教育部绿色农药和农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2005-10-02 修回日期:2006-03-06 发布日期:2006-07-26
  • 通讯作者: 宋宝安

Green Synthesis of O,O'-Dialkyl α-(4-Trifluoromethylanilino)-substitutented Benzylphos-phonate

WAN Qiong-Qiong,SONG Bao-An*,ZHANG Guo-Ping,JIN Lin-Hong
HU De-Yu,YANG Song,LIU Gang   

  1. (Key Laboratory of Green Pesticide and Agricultural Bioengineering of Ministry of Education, Research and
    Development Center of Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2005-10-02 Revised:2006-03-06 Published:2006-07-26
  • Contact: SONG Bao-An

采用微波辐射﹑离子液体和无溶剂无催化剂三种绿色合成方法, 分别进行了以亚磷酸酯、邻氟苯甲醛和对三氟甲基苯胺为原料的类Mannich一锅法合成反应研究, 经合成筛选, 优选出控制反应温度100 ℃、无溶剂和无催化剂加热反应15 min的合成方法, 实验结果表明该方法经济、简便、产率高、反应时间短及对环境友好.

关键词: α-氨基膦酸酯, 绿色合成, 无溶剂无催化剂

The Mannich-type addition of O,O'-dialky phosphite to 2-fluorobenzaldehyde and 4-trifluoro- methylaniline was carried out in one pot by means of adopting three kinds of green synthetic methods, microwave irradiation, ionic liquid and free solvent-catalyst condition. According to the results, the synthetic method was optimized without catalyst and solvent at 100 ℃ and 15 min, and it was economic, convenient, high yields, timesaving and environment friendly.

Key words: green synthesis, free solvent-catalyst, α-aminophosphonate