有机化学 ›› 2012, Vol. 32 ›› Issue (10): 2003-2006.DOI: 10.6023/cjoc201204007 上一篇    下一篇

研究简报

莪术醇在Woodward-Prévost反应条件下的产物研究

郭平a, 刘剑敏a, 叶发青a, 李校堃a, 姚其正b   

  1. a 温州医学院药学院 温州 325035;
    b 中国药科大学药学院 南京 210009
  • 收稿日期:2012-04-05 修回日期:2012-05-28 发布日期:2012-06-04
  • 通讯作者: 叶发青 E-mail:gp_0713@163.com

Some Products of Curcumol under the Woodward-Pr関ost Conditions

Guo Pinga, Liu Jianmina, Ye Faqinga, Li Xiaokuna, Yao Qizhengb   

  1. a School of Pharmacy, Wenzhou Medical College, Wenzhou 325035;
    b School of Pharmacy, China Pharmceutical University, Nanjing 210009
  • Received:2012-04-05 Revised:2012-05-28 Published:2012-06-04

莪术醇分子中含有末端双键, 将其置于Woodward-Prévost反应条件下, 并未获得α-碘代乙酸酯、双乙酸酯、羟基乙酸酯等衍生物, 而得到几个不同产物AC. 产物AC通过质谱、核磁共振和X衍射分析确证结构, 并对产物产生的可能过程进行了讨论.

关键词: 莪术醇, 衍生物, Woodward-Prévost反应

Curcumol reacts under the Woodward-Prévost conditions providing not usual products but several unexpected derivatives AC. The structures of compounds AC were determined by MS, NMR and X-ray diffraction analysis. A plausible mechanism involved in their formation was discussed.

Key words: curcumol, derivatives, Woodward-Pr関ost reaction