有机化学 ›› 2014, Vol. 34 ›› Issue (2): 278-291.DOI: 10.6023/cjoc201308031 上一篇    下一篇

综述与进展

Pd-NHC络合物催化交叉偶联反应的新进展

倪晨b, 沈安a,b, 曹育才a,b, 叶晓峰a,b   

  1. a 上海市聚烯烃催化技术重点实验室 上海 200062;
    b 上海化工研究院 有机化工研究所 上海 200062
  • 收稿日期:2013-08-26 修回日期:2013-10-28 出版日期:2014-02-25 发布日期:2013-11-14
  • 通讯作者: 曹育才 E-mail:caoyc@srici.cn
  • 基金资助:

    上海市科学技术委员会(Nos.12NM0504500和13XD1421700)资助项目.

New Progress in Crossing Coupling Reactions Catalyzed by Pd-NHC Complexes

Ni Chenb, Shen Ana,b, Cao Yucaia,b, Ye Xiaofenga,b   

  1. a Shanghai Key Laboratory of Catalysis Technology for Polyolefins, Shanghai 200062;
    b Organic Chemistry Division, Shanghai Research Institute of Chemical Industry, Shanghai 200062
  • Received:2013-08-26 Revised:2013-10-28 Online:2014-02-25 Published:2013-11-14
  • Supported by:

    Project supported by the Shanghai Municipal Science and Technology Commission (Nos. 12NM0504500, 13XD1421700).

钯催化的交叉偶联反应能非常有效且方便构建碳-碳键并应用于农药、医药、新型材料和有机中间体等领域. 多年来,各种不同结构的配体以及新型的催化体系被不断开发出来. 其中N-杂环卡宾(NHC)配体毒性低,稳定性好,同时在反应过程中具备良好的配位能力,因而被作为新一代催化体系应用于各种不同的交叉偶联反应中. 根据NHC结构特点综述了近年来新开发的Pd-NHC催化剂及其在多种交叉偶联反应中的应用.

关键词: 钯催化剂, N-杂环卡宾, 交叉偶联反应

Palladium-catalyzed cross-coupling reaction has become one of the most powerful and convenient protocol for the construction of carbon-carbon bonds in agrochemistry, pharmaceutical chemistry, materials and synthetic chemistry. In recent years, a variety of different structures of ligands and novel catalysts have been widely explored. Wherein N-heterocyclic carbene (NHC) ligands are employed as new generation catalysts in cross-coupling reactions due to low toxicity, good stability as well as appropriate coordination ability. The application of new developed Pd-NHC catalysts in cross-coupling reactions is reviewed according to the characteristics of NHC structures.

Key words: Pd catalyst, N-heterocyclic carbene (NHC), cross-coupling reaction