Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2098-2107.DOI: 10.6023/cjoc201303020 Previous Articles     Next Articles



林岱宗, 王江, 柳红   

  1. 中国科学院上海药物研究所 新药研究国家重点实验室 上海 201203
  • 收稿日期:2013-03-15 修回日期:2013-04-23 发布日期:2013-05-09
  • 通讯作者: 柳红
  • 基金资助:

    国家杰出青年科学基金(No. 81025017)资助项目

Recent Developments in the Synthesis of Fluorine-Containing β-Amino Acids and β-Lactams

Lin Daizong, Wang Jiang, Liu Hong   

  1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203
  • Received:2013-03-15 Revised:2013-04-23 Published:2013-05-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81025017).

Fluorine-containing β-amino acids and β-lactams have attracted appreciable attention due to their wide application in organic chemistry, drug discovery, and protein biology. Accordingly, the development of efficient synthetic methods is of considerable interest in academia and industry. The synthesis and resolution are achieved. This review briefly summarizes the recent development in the methodologies for the synthesis of fluorine-containing β-amino acids and β-lactams with classification by the species of the fluorine-containing β-amino acids (α-fluorinated β-amino acids, α-trifluoromethyl β-amino acids, and β-trifluoromethyl β-amino acids).

Key words: fluorine-containing β-amino acid, fluorine-containing β-lactam, synthesis