Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (4): 761-766.DOI: 10.6023/cjoc201310038 Previous Articles     Next Articles


赵华绒a, 王玲a, 王昱丹b   

  1. a 浙江大学化学系 杭州 310027;
    b 绍兴文理学院化学化工学院 绍兴 312000
  • 收稿日期:2013-10-25 修回日期:2013-12-05 发布日期:2013-12-19
  • 通讯作者: 赵华绒
  • 基金资助:

    浙江省自然科学基金(Nos. LY12B02015,Y4080234)资助项目.

A Novel and Green Method for the Synthesis of 4-Thiazolidinones with the Sources of 2-Chloroacetamide and Thioureas

Zhao Huaronga, Wang Linga, Wang Yudanb   

  1. a Department of Chemistry, Zhejiang University, Hangzhou 310027;
    b College of Chemistry & Chemical Engineering, Shaoxing University, Shaoxing 312000
  • Received:2013-10-25 Revised:2013-12-05 Published:2013-12-19
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (Nos. LY12B02015, Y4080234).

A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the sources of substituted thioureas and 2-chloroacetamide in the ionic liquids. This method offers several advantages like high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.

Key words: 4-thiazolidinones, 2-chloroacetamide, ionic liquid, mechanism, green